RNA

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IncRNAs

What is a Long Non-Coding RNA? Long non-coding (lnc) RNAs are defined as non-protein coding RNAs distinct from housekeeping RNAs such as tRNAs, rRNAs, and snRNAs, and independent from small RNAs with specific molecular processing machinery such as micro- or piwi-RNAs1. The co-occurrence of massively parallel sequencing technology applied to RNA and the recognition that […]

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RNA Interference And Clinical Applications

Considering the two most common types of diseases caused by mRNA activity, one of them is virus-related and the other is cancer-related1. These diseases cause viral or abnormal proteins to be encoded by mRNA1. For instance, some ORFs found in coronaviruses encode viral structural proteins2. After viral cells enter the body, they undergo RNA translation

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Pseudouridine

The mesmerizing world of RNAs is expansive, and so are their modifications and bases. The first notable feature of RNAs is that containing pseudouridine (5-ribosyluracil). This nucleoside is a C5 isomer of uracil base and is present in tRNAs, rRNAs, small nuclear RNAs (snRNAs), small nucleolar RNAs (snoRNAs), and mRNAs1,2.It was found in 1951 as

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